| ncRNA name | hsa-miR-155 |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | retinas |
| Methods | RT-PCR, Northern blot |
| Expression pattern | up-regulated |
| Functional description | miR-9, miR-125b, miR-146a and miR-155 are progressively up-regulated in both AD and AMD. This quartet of up-regulated miRNAs in turn down-regulate a small brain- and retinal-cell-relevant family of target mRNAs, including that encoding complement factor H (CFH), a major negative regulator of the innate immune and inflammatory response. |
| PubMed ID | 22509485 |
| Year | 2012 |
| Title | Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD). |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.